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beta adrenergic receptor
beta-adrenergic receptors mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins
Pharmacology:
1) beta-adrenergic receptor antagonists (beta blockers) are used in clinically for their pharmacologic effects:
a) negative inotropic effects on the heart
b) inhibitory effects on conduction through the AV node
2) beta-adrenergic receptor agonist are used clinically for indications depending upon their specificity
a) beta-1 adrenergic receptor agonist
b) beta-2 adrenergic receptor agonist
Interactions
molecular events
Related
beta adrenergic receptor antagonist (beta-blocker)
beta-adrenergic receptor agonist
gene
Specific
beta-1 adrenergic receptor; beta-1 adrenoreceptor; beta-1 adrenoceptor (ADRB1, ADRB1R, B1AR)
beta-2 adrenergic receptor; beta-2 adrenoreceptor; beta-2 adrenoceptor (ADRB2, ADRB2R, B2AR)
beta-3 adrenergic receptor; beta-3 adrenoreceptor; beta-3 adrenoceptor (ADRB3, ADRB3R, B3AR)
General
adrenergic receptor
glycoprotein
phosphoprotein
Properties
COMPARTMENT: cellular membrane
MOTIF: N-glycosylation site {N-TERMINAL}
ligand-binding site
SITE: WITHIN-MEMBRANE-DOMAINS
FOR-BINDING-OF: norepinephrine
epinephrine
transmembrane domain (7)
Ser phosphorylation site {L5}
cysteine residue {CYTOPLASMIC-TAIL}
MODIFICATION: palmitate
COMPARTMENT: membrane
Ser phosphorylation site {CYTOPLASMIC-TAIL}
Ser phosphorylation site {C-TERMINAL}
References
Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 748