Search
beta-adrenergic receptor agonist
Adverse effects:
1) hypokalemia, intracellular shift of K+
2) metabolic acidosis
3) hypomagnesemia
4) tachycardia
5) tremor
6) anxiety
7) palpitations
8) hypertension
9) cardiac arrhythmias
10) exacerbation of prostatism
11) paradoxic bronchospasm to aerosolized beta-adrenergic agents (especially long-acting agents, salmeterol, formoterol [2]
a) tachyphylaxis
b) preservatives & propellants
12) adverse effects more likely in elderly & in patients with cardiovascular, hepatic & neurologic disorders
Drug interactions:
- beta adrenergic agonists may potentiate the effects of MAO inhibitors & tricyclic antidepressants
Mechanism of action:
- stimulation of cAMP formation in selected cell population
Interactions
molecular events
drug adverse effects (more general classes)
Related
antiarrhythmic agent, Group II
beta adrenergic receptor
Specific
arbutamine
beta-1 adrenergic receptor agonist
beta-3 adrenergic receptor agonist
bitolterol (Tornalate)
ephedrine
epinephrine; adrenaline (Sus-Phrine, Vapronefrin, Epifrin, Glaucon, Auvi-Q, Allerject)
inhaled beta-2 adrenergic receptor agonist
isoetharine (Bronkosol, Bronkometer)
isoproterenol
long-acting beta adrenergic receptor agonist (LABA)
metaproterenol (Alupent, Metaprel, Dey-Dose)
pirbuterol (Maxair)
General
adrenergic receptor agonist
Properties
AGONIST-FOR: beta adrenergic receptor
References
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 741
- Prescriber's Letter 12(9): 2005
The Safety of Long-Acting Beta-2 Agonists in Patients with Asthma
Detail-Document#: 210907
(subscription needed) http://www.prescribersletter.com
- US Department of Health and Human Services. National
Institutes of Health. National Heart, Lung and Blood Institute.
Expert Panel Report: Guidelines for the Diagnosis and Management
of Asthma-Update on selected topics 2002.
- Salpeter SR et al,
Meta-analysis: Effect of long-acting beta agonists on severe
asthma exacerbations and asthma-related deaths.
Ann Intern Med 2006; 144:904
PMID: 16754916
- Glassroth J
The role of long-acting beta-agonists in the management of
asthma. Analysis, meta-analysis, and more analysis,
Ann Intern Med 2006; 144:936
PMID: 16754915
- Bateman E et al,
Effects of adding salmeterol in inhaled corticosteroids on
serious asthma-related events.
Ann Intern Med 2008, June 3
PMID: 18523132
- Weiss KB
Drug safety and salmeterol: The controversy continues.
Ann Intern Med 2008, June 3
PMID: 18523132
Component-of
beta-adrenergic receptor agonist/expectorant/xanthine