Search
actin, cytoplasmic 1; beta-actin (ACTB)
Function:
- cytoplasmic actin
- involved in cell motility
- ISGylated
- polymerization of globular actin (G-actin) leads to a structural filament (F-actin)
- ach actin can bind to 4 others
- identified in a mRNP granule complex
- component of the BAF complex
- found in a complex with XPO6, Ran, ACTB & PFN1
- component of the MLL5-L complex
- interacts with XPO6 & EMD
Structure: belongs to the actin family
Compartment:
- cytoplasm, cytoskeleton
- localized in cytoplasmic mRNP granules containing untranslated mRNAs
Pathology:
- defects in ACTB are a cause of dystonia juvenile-onset
Specific
G-actin
General
actin
phosphoprotein
Properties
SIZE: entity length = 375 aa
MW = 42 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyr phosphorylation site {Y53}
Tyr phosphorylation site {Y91}
Tyr phosphorylation site {Y166}
Tyr phosphorylation site {Y169}
Tyr phosphorylation site {Y198}
Tyr phosphorylation site {Y218}
Tyr phosphorylation site {Y294}
Thr phosphorylation site {T318}
Database Correlations
OMIM correlations
MORBIDMAP 102630
UniProt P60709
Pfam PF00022
Entrez Gene 60
Kegg hsa:60; -.
References
- UniProt :accession P60709
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/ACTBID42959ch7p22.html
- NIEHS-SNPs
http://egp.gs.washington.edu/data/actb/
Component-of
mRNP granule complex