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beta-2 microglobulin in serum
Indications:
- patients with systemic lupus erythematosus have anti beta-2 microglobulin
- patients with Felty's syndrome have circulating immune complexes containing beta-2 microglobulin
- monitoring may predict progression of HIV patients to AIDS, leukemia or lymphoma
Reference interval:
1) 0.30 mg/dL, age < 28 days (neonate)
2) 0.19 mg/dL, age < 60 years
3) 0.21 mg/dL, age = 60-69 years
4) 0.24 mg/dL, age > 70 years
Specimen:
1) analyze fresh or store at 4 degrees C or < 72 h
2) stable frozen at -20 degrees C for 6 months, or -70 degrees C indefinitely
Interferences:
- serum levels increased by
a) cyclosporin
b) lithium
Increases:
- increased in a wide variety of conditions characterized by increased cell turnover; these include:
a) inflammation
b) autoimmune disorders
c) lymphoid malignancies
d) viral infections
- increases also seen with:
a) amyloidosis
b) dialysis
c) aging [3]
Related
beta-2-microglobulin (B2M)
Specific
beta-2-microglobulin.tumor marker in serum
General
beta-2 microglobulin in body fluid
References
- Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz
ed, WB Saunders, Philadelphia, 1995
- Beta-2-Microglobulin, Serum/Plasma
Laboratory Test Directory ARUP: 80053
- Smith LK, He Y, Park JS et al
beta2-microglobulin is a systemic pro-aging factor that impairs
cognitive function and neurogenesis.
Nat Med. 2015 Jul 6. doi: 10.1038/nm.3898. [Epub ahead of print]
PMID: 26147761
Component-of
ovarian cancer 5 protein panel