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beta-2 microglobulin in CSF

Reference interval: - 1.3-1.7 mg/L Increases: 1) acute leukemia 2) lymphoma with CNS involvement 3) aging [3] Specimen: 1) centrifuge before analysis 2) analyze fresh or store at 4 degrees C for < 72 hours 3) stable frozen at -20 degrees C for 6 months, or indefinitely at -70 degrees C 4) specimens should NOT contain blood

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beta-2-microglobulin (B2M) cerebrospinal fluid

General

beta-2 microglobulin in body fluid

References

  1. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
  2. Beta-2-Microglobulin, CSF Laboratory Test Directory ARUP: 80054
  3. Smith LK, He Y, Park JS et al beta2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat Med. 2015 Jul 6. doi: 10.1038/nm.3898. [Epub ahead of print] PMID: 26147761