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beta-2-microglobulin (B2M)
Function:
- beta-chain (light chain) of MHC class 1 molecules
Structure:
- belongs to the beta-2-microglobulin family
- contains 1 Ig-like C1-type domain (immunoglobulin-like)
Compartment: secreted
Expression:
- synthesized by all nucleated cell types
Pathology:
- age-associated increase in plasma levels in humans & mice [3]
- higher levels accumulate in plasma of patients with ESRD
- glycation of Ile-21 is observed in long-term hemodialysis patients
- may be deposited in tissues in some types of amyloidosis
- defects in B2M are the cause of hypercatabolic hypoproteinemia
Comparative biology:
- B2M negatively regulates older age-associated cognitive regenerative function in hippocampus of mice [3]
- exogenous B2M injected systemically impairs hippocampal- dependent cognitive function & neurogenesis in young mice [3]
Related
amyloidosis
beta-2 microglobulin in body fluid
beta-2-microglobulin amyloid Ag in tissue
beta-2-microglobulin.tumor marker in serum
General
beta 2 globulin
microglobulin
protein subunit
Properties
SIZE: entity length = 119 aa
MW = 14 kD
MOTIF: signal sequence {1-20}
immunoglobulin superfamily domain {25-113}
MOTIF: cysteine residue {C45}
MODIFICATION: cysteine residue {C100}
cysteine residue {C100}
MODIFICATION: cysteine residue {C45}
Database Correlations
OMIM correlations
UniProt P61769
Pfam PF07654
Entrez Gene 567
Kegg hsa:567
References
- UniProt :accession P61769
- Wikipedia; beta-2-microglobulin
http://en.wikipedia.org/wiki/beta-2-microglobulin
- Smith LK, He Y, Park JS et al
beta2-microglobulin is a systemic pro-aging factor that impairs
cognitive function and neurogenesis.
Nat Med. 2015 Jul 6. doi: 10.1038/nm.3898. [Epub ahead of print]
PMID: 26147761
Component-of
HLA class I histocompatibility antigen protein P5 (HLA complex protein P5, protein P5-1) (HCP5)