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beta-1 adrenergic receptor; beta-1 adrenoreceptor; beta-1 adrenoceptor (ADRB1, ADRB1R, B1AR)
Function:
- beta-adrenergic receptor
- binds epinephrine & norepinephrine with approximately equal affinity
- interacts with GOPC, MAGI3 & DLG4
- homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase
Structure:
- the PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 & DLG4 & plays a role in subcellular location of the receptor
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane
- localized at the plasma membrane
- found in the Golgi upon GOPC overexpression Comparative-biology:
- polymorphism(s) in the gene may confer tendency to fibrosis & response of myocardial tissue to beta-blockers in mice [3]
Related
beta-1 adrenergic receptor agonist
beta-1 adrenergic receptor antagonist (beta-1 blocker)
gene
General
beta adrenergic receptor
Properties
SIZE: entity length = 477 aa
MW = 51 kD
COMPARTMENT: golgi
MOTIF: exoplasmic domain {1-59}
MOTIF: N-glycosylation site {N15}
transmembrane domain {60-83}
cytoplasmic loop {84-96}
transmembrane domain {97-120}
exoplasmic loop {121-131}
MOTIF: cysteine residue {C131}
MODIFICATION: cysteine residue {C209}
transmembrane domain {132-155}
cytoplasmic loop {156-175}
transmembrane domain {176-199}
exoplasmic loop {200-221}
MOTIF: cysteine residue {C209}
MODIFICATION: cysteine residue {C131}
transmembrane domain {222-245}
cytoplasmic loop {246-325}
MOTIF: Ser phosphorylation site {S312}
transmembrane domain {326-349}
exoplasmic loop {350-356}
transmembrane domain {357-380}
cytoplasmic domain {381-477}
MOTIF: cysteine residue {C392}
MODIFICATION: palmitate
COMPARTMENT: membrane
Ser phosphorylation site {S412}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 474-477
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM correlations
MORBIDMAP 109630
UniProt P08588
Pfam PF00001
Entrez Gene 153
References
- UniProt :accession P08588
- SeattleSNPs
http://pga.gs.washington.edu/data/adrb1/
- Mialet Perez J, Rathz DA, Petrashevskaya NN et al.
Beta 1-adrenergic receptor polymorphisms confer differential
function and predisposition to heart failure.
Nat Med. 2003 Oct;9(10):1300-5. Epub 2003 Sep 14.
PMID: 14502278