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BDNF genotyping
Clinical significance:
- BDNF Val66Val polymorphism most common (68%)
- elderly with the BDNF Val66Val polymorphism benefit greatly from physical activity [1]
- greater physical activity levels were associated with larger volumes in the temporal lobe & hippocampus
- elderly with BDNF Val66Met polymorphism did not benefit from exercise
- greater physical activity was associated with smaller temporal-lobe volume [1]
Related
brain-derived neurotrophic factor; BDNF; abrineurin (BDNF)
General
genotyping (allele testing)
References
- Brown BM et al.
Influence of BDNF Val66Met on the relationship between physical
activity and brain volume.
Neurology 2014 Oct 7; 83:1345
PMID: 25186863