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B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B, radiation-induced tumor suppressor gene 1 protein, hRit1, COUP-TF-interacting protein 2, BCL11B, CTIP2, RIT1)
Function:
1) tumor-suppressor protein
2) role in P53-signaling pathway (putative)
3) regulates both differentiation & survival during thymocyte development
4) represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element
5) interacts with TFCOUP1, SIRT1, ARP1 & EAR2
Structure:
- contains 6 C2H2-type zinc fingers
Compartment:
- nucleus
Alternative splicing: named isoforms=2
Expression: highly expressed in brain
Pathology:
- role in T-cell lymphomas
- highly expressed in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma
General
anti-oncoprotein (tumor suppressor protein)
bcl protein (B-cell leukemia/lymphoma protein)
zinc finger protein
Properties
SIZE: MW = 96 kD
entity length = 894 aa
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 221-251
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 427-454
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 455-482
EFFECTOR-BOUND: Zn+2
glutamate-rich region {529-553}
MOTIF: glutamate residue (SEVERAL)
glycine-rich region {569-661}
Zn finger C2H2-type
SITE: 796-823
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 824-853
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 854-884
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 606558
UniProt Q9C0K0
Pfam PF00096
References
- UniProt :accession Q9C0K0
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/BCL11BID392.html