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B-cell receptor-associated protein 31 (BCR-associated protein Bap31, p28 Bap31, protein CDM, 6C6-AG tumor-associated antigen, BCAP31, BAP31, DXS1357E)
Function:
1) role in anterograde transport of membrane proteins from endoplasmic reticulum to Golgi
2) CASP8-mediated apoptosis (putative)
- Cleaved by CASP8 & other caspases
3) homodimer & heterodimer with BCAP29
4) binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 &/or BCL2L1
5) interacts with VAMP3, VAMP1 & membrane IgD immunoglobulins
6) interact with ACTG1 & non-muscle myosin 2
Compartment:
- endoplasmic reticulum-Golg intermediate compartment
- may shuttle between the ER & the intermediate compartment/ cis-Golgi
Expression: ubiquitous
Pathology:
- microdeletions in BCAP31 are involved in the contiguous ABCD1/DXS1375E deletion syndrome (CADDS) [MIM:300475]. Patients manifest profound neonatal hypotonia, subsequent failure to thrive, and cholestatic liver disease
General
transmembrane 3 protein
Properties
SIZE: MW = 28 kD
entity length = 245 aa
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: exoplasmic domain {1-5}
transmembrane domain {6-26}
cytoplasmic loop {27-42}
transmembrane domain {43-63}
exoplasmic loop {64-101}
transmembrane domain {102-122}
cytoplasmic domain {123-245}
MOTIF: proteolytic site {163-164}
proteolytic site {237-238}
ER retionsion {242-245}
Database Correlations
OMIM correlations
UniProt P51572
Pfam PF05529
References
UniProt :accession P51572