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Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis (BBC3, PUMA)
Function:
- mediator of p53/TP53-dependent & p53/TP53-independent apoptosis
- interacts with MCL1 & BCL2A1 (putative)
- interacts with BCL2 & BCL2L1/BCL-XL
- isoform 3 fails to show any growth-inhibitory or apoptotic activity
- isoform 3 does not interact with BCL2
Structure: belongs to the Bcl-2 family
Compartment:
- mitochondria
- localized to the mitochondria in order to induce cytochrome c release
Alternative splicing: named isoforms=4
Expression:
- ubiquitously expressed
- induced by DNA damage, glucocorticoid treatment, growth factor deprivation & p53/TP53
General
mitochondrial protein
Properties
SIZE: entity length = 261 aa
MW = 26 kD
COMPARTMENT: mitochondria
MOTIF: arginine-rich region {32-105}
MOTIF: arginine residue (SEVERAL)
proline-rich region
SITE: 37-124
MOTIF: proline residue (SEVERAL)
glycine-rich region {134-180}
alanine-rich region {194-197}
MOTIF: alanine residue (SEVERAL)
Database Correlations
OMIM 605854
SWISS-PROT correlations
Entrez Gene 27113
Kegg hsa:27113
References
- UniProt :accession Q96PG8
- UniProt :accession Q9BXH1
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/BBC3ID759ch19q13.html