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Bcl-2 associated protein X (BAX)

Function: - inhibits bcl-2 through formation of heterodimers - binding of bcl-2 to Bax occurs via BH1 domain & BH2 domain - Bax also forms homodimers - oligomerization of bax leads to integration in the mitochondrial outer membrane & channel formation - component of permeability transition pore complex (PTPC) - cooperates with constitutive mitochondrial protein adenosine nucleotide translocator-1 (ANT-1) to increase mitochondrial membrane permeability & trigger cell death - induces release of cytochrome c from mitochondria Compartment: - translocates from cytosol to mitochondria during apoptosis

Related

ADP/ATP translocase-1 (adenine nucleotide translocator 1, ANT 1, ADP-ATP carrier protein 1, solute carrier family 25 member 4, heart/skeletal ADP/ATP carrier protein, SLC25A4, ANT1) B-cell leukemia-2 (bcl-2) protein bax gene cytochrome c (CYCS)

General

bax subfamily protein membrane protein

Properties

COMPARTMENT: cellular membrane MOTIF: BH3 domain NAME: BH3 domain SITE: L59-N73 BH1 domain NAME: BH1 domain SITE: D98-S118 FOR-BINDING-OF: apoptosis regulator Bcl-2 BH2 domain NAME: BH2 domain SITE: G150-S165 FOR-BINDING-OF: apoptosis regulator Bcl-2 transmembrane domain {T172-L192}

References

  1. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19. PMID: 8358790
  2. Martin SJ, Green DR, Cotter TG. Dicing with death: dissecting the components of the apoptosis machinery. Trends Biochem Sci. 1994 Jan;19(1):26-30. Review. PMID: 8140617
  3. Korsmeyer SJ. Regulators of cell death. Trends Genet. 1995 Mar;11(3):101-5. Review. PMID: 7732571
  4. Yin XM, Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature. 1994 May 26;369(6478):321-3. PMID: 8183370
  5. Marzo I et al Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science. 1998 Sep 25;281(5385):2027-31. PMID: 9748162
  6. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell. 2000 Sep 15;102(6):849-62. PMID: 11030628
  7. Antonsson B, Martinou JC. The Bcl-2 protein family. Exp Cell Res. 2000 Apr 10;256(1):50-7. Review. PMID: 10739651
  8. Entrez Gene :accession 581

Databases & Figures

OMIM 600040 UniProt Q07812 Entrez Gene 581 KEGG correlations p53/apoptosis