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basophil
Function:
- immediate hypersentitivity reactions
- some delayed hypersensitivity reactions
- basophils granules contain
a) histamine
b) eosinophil chemotactic factor-A (ECF-A)
c) heparin
d) peroxidase
- basophils also synthesize & release
a) slow-reacting substance of anaphylaxis (SRS-A)
b) platelet-activating factor (PAF)
Physiology:
- basophils develop from a progenitor cell resembling a myeloblast separate from neutrophil, monocyte, eosinophil progenitors
- the earliest recognizable basophil precursor is the basophilic meylocyte
- maturation time in the bone marrow is ~ 7 days
- life span in peripheral blood is similar to eosinophils (~ 18 hours)
- basophils are not found in tissues
- basophils do not seem to give rise to mast cells
Biochemistry:
- mature basophils express CD32
- basophils bind IgE
- antigen binding basophil-bound IgE results in degranulation of basophils with release of histamine, ECF-A, heparin, peroxidase, SRS-A, PAF
- this results in accumulation of eosinophils which contain substances that tend to counteract the effects of basophils [1]
Laboratory:
- component of complete blood count with differential
- normal basophil count is 0-100/uL, & 0.4% of circulating WBC
- labs with Loincs
- basophils in specimen
- basophils in nose
- basophils in body fluid
- basophils in amniotic fluid
- basophils in blood
- basophils in cord blood
- basophils in bronchial fluid
- basophils in CSF
- basophils in dialysis fluid
- basophils in pericardial fluid
- basophils in peritoneal fluid
- basophils in pleural fluid
- basophils in sputum
- basophils in synovial fluid
- basophils in vitreous fluid
Related
basophilia
basophils in blood
General
granulocyte
References
- Henry's Clinical Diagnosis & Management by Laboratory Methods,
21st edition, McPherson RA & Pincus MR (es), W.B. Saunders Co.,
Philadelphia, PA. 2007, page 496