Search
basaloid squamous cell carcinoma
High grade agressive squamous cell carcinoma variant.
Pathology: Predilection for head & neck, occurs in larynx, hypopharynx, tonsils, base of tongue, oral cavity, nasopharynx, trachea, sinonasal tract.
Microscopic pathology:
- predominantly basaloid appearing cells
- hyperchromatic nuclei
- marked nuclear pleomorphism
- eosinophilic to amphophilic clear cytoplasm
- variable nucleoli
- confluent foci of central necrosis
- individual cell necrosis
- peripheral nuclear pallisading
- foci of squamous cell differentiation
- intermixture of squamous & basaloid cells
- infiltrative, mostly lobular or solid Immunohistochemistry [1]:
- pan-cytokeratin: +
- EMA: + variable amount & pattern
- CAM 5.2: + 12/14
- CEA: + 4/14
- CK7: + 10/14
- CK20: + 1/14 focal
- 34betaE12: + 12/14
- S100 + 6/14
- NSE: + 10/14
- GFAP: + 2/14
- vimentin: + 8/14
- muscle specific actin (HHF35): + 7/14
- Ewing's marker (MIC-2): + 7/14
- chromogranin, synaptophysin, neurofilament protein, HMB-45, desmin, leukocyte common antigen: negative
Differential diagnosis:
- undifferentiated small cell carcinoma
Interactions
disease interactions
General
squamous cell carcinoma (SCC)
References
- Wieneke et al. Cancer 85:841-854, 1999