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Bcl-2 homologous antagonist/killer; apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7 (BAK1, BAK, BCL2L7, CDN1)

Function: - promotes cell death & counteracts protection from apoptosis by bcl-2 - inhibits bcl-2 through formation of heterodimers - counteracts protection from apoptosis by adenovirus homolog E1B 19k protein - low micromolar levels of Zn+2 inhibit the promotion of apoptosis - interacts with BCL2A1 (putative) - forms heterodimers with BCL2, E1B 19k protein, & BCL2L1 isoform Bcl-XL Structure: - homodimer; formation of the homodimer is Zn+2-dependent - binding of bcl2 to Bak1 occurs via BH1 domain & BH2 domain - Bak1 also forms homodimers - intact BH3 motif is required by BIK, BID, BAK, BAD & BAX for their pro-apoptotic activity & for their interaction with anti-apoptotic members of the Bcl-2 family - belongs to the Bcl-2 family Compartment: mitochondrial outer membrane Expression: - expressed in wide variety of cell types - highest levels in the heart & skeletal muscle

Related

Bcl-2 homologous antagonist/killer 2; apoptosis regulator BAK-2 (BCL2L7P1 BAK2)

General

bax subfamily protein mitochondrial protein pro apoptotic protein

Properties

SIZE: entity length = 211 aa MW = 23 kD COMPARTMENT: mitochondria MOTIF: BH3 {74-88} BH1 {117-136} Zn+2-binding site SITE: 160-160 Zn+2-binding site SITE: 164-164 BH2 {169-184} transmembrane domain {188-205}

Database Correlations

OMIM 600516 UniProt Q16611 Pfam PF00452 Entrez Gene 578 KEGG correlations

References

  1. Farrow SN, White JH, Martinou I, Raven T, Pun KT, Grinham CJ, Martinou JC, Brown R. Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature. 1995 Apr 20;374(6524):731-3. Erratum in: Nature 1995 Jun 1;375(6530):431. PMID: 7715729
  2. Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC. Induction of apoptosis by the Bcl-2 homologue Bak. Nature. 1995 Apr 20;374(6524):733-6. PMID: 7715730
  3. Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, Barr PJ. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature. 1995 Apr 20;374(6524):736-9. PMID: 7715731
  4. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: 11165519
  5. Entrez Gene :accession 578
  6. UniProt :accession Q16611
  7. NIEHS-SNPs http://egp.gs.washington.edu/data/bak1/