brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1-associated protein 2, protein BAP2, insulin receptor substrate p53, IRSp53, insulin receptor substrate protein of 53 kD, insulin receptor substrate p53/p58, IRSp53/58, IRS-58, Fas ligand-associated factor 3, FLAF3, BAIAP2)

Function: 1) adapter protein 2) links membrane-bound small G-proteins to cytoplasmic effector proteins 3) CDC42-mediated reorganization of actin cytoskeleton 4) RAC1-mediated membrane ruffling 5) regulation of actin cytoskeleton by WASF family members & Arp2/3 complex 6) neurite growth 7) acts syngeristically with ENAH to promote filipodia formation. 8) homodimer 9) interacts with CDC42 & RAC1 activated by GTP binding 10) interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1, WASF2 11) interacts with ENAH after recruitment of CDC42 12) interacts with TIAM1, DIAPH1 13) IMD domain forms a coiled coil - the isolated domain can induce actin bundling & filopodia formation 14) in the absence of G-proteins, intramolecular interaction between the IMD & theSH3 domain gives rise to an auto- inhibited state 15) interaction of the IMD with RAC1 or CDC42 leads to activation. 16) SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1, ENAH 17) phosphorylated on TYR by INSR in response to insulin Compartment: - cytoplasm, peripheral membrane - detected in filopodia & close to membrane ruffles Alternative splicing: named isoforms=6 Expression: - isoform 1 & isoform 4 are expressed almost exclusively in brain

Properties

SIZE: MW = 61 kD entity length = 552 aa COMPARTMENT: cytoplasm MOTIF: IMD {1-250} MOTIF: coiled coil {132-153} Tyr phosphorylation site {Y337} src homology 3 [SH3] domain SITE: 374-437 Tyr phosphorylation site {Y491} Tyr phosphorylation site {Y505}

Database Correlations

OMIM 605475 UniProt Q9UQB8 PFAM correlations

References

UniProt :accession Q9UQB8