WW domain-containing protein 3; membrane-associated guanylate kinase, WW & PDZ domain-containing protein 1; BAI1-associated protein 1; BAP-1; membrane-associated guanylate kinase inverted 1; MAGI-1; atrophin-1-interacting protein 3; AIP-3; WWP3; trinucleotide repeat-containing gene 19 protein (MAGI1, AIP3, BAIAP1, BAP1, TNRC19)

Function: 1) may play a role as scaffolding protein at cell-cell junctions 2) may regulate acid-induced ACCN3 currents 3) interacts with: a) SYNPO, DRPLA via WW domain b) ACTN4 via PDZ domain 5 c) NET1 via PDZ domain 1 d) BAI1, ESAM, LRP2, CXADR, ACCN3, AMOT 4) isoform 2 interacts with CTNNB1 Structure: - contains 1 guanylate kinase-like domain - contains 6 PDZ domain (DHR domain)s - contains 2 WW domains Compartment: - membrane-associated-associated - localizes to epithelial cells tight junctions Alternative splicing: - named isoforms=7 - additional isoforms seem to exist Expression: - widely expressed - not expressed in skeletel muscle - isoform 1, isoform 2 & isoform 6 are highly expressed in colon, kidney, lung, liver, & pancreas - isoform 5 is predominantly expressed in brain & heart - isoform 3 & isoform 4 are highly expressed in pancreas & brain

General

phosphoprotein scaffold protein

Properties

SIZE: entity length = 1491 aa MW = 165 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: PDZ domain NAME: PDZ domain SITE: 17-105 domain {96-287} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 103-110 HOMOLOGY: guanylate kinase WW domain (W/rsp5/WWP domain) {300-333} WW domain (W/rsp5/WWP domain) {359-392} MOTIF: Tyr phosphorylation site {Y376} glutamine-rich region {402-421} MOTIF: glutamine residue (SEVERAL) PDZ domain NAME: PDZ domain SITE: 472-554 PDZ domain NAME: PDZ domain SITE: 643-721 MOTIF: glycine-rich region {662-665} PDZ domain NAME: PDZ domain SITE: 813-895 MOTIF: Tyr phosphorylation site {Y866} FCHSD2 interaction NAME: FCHSD2 interaction SITE: 970-1066 MOTIF: glycine-rich region {978-988} PDZ domain NAME: PDZ domain SITE: 1124-1206 alanine-rich region {1341-1344} MOTIF: alanine residue (SEVERAL) arginine-rich region {1398-1401} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S1490}

Database Correlations

OMIM 602625 UniProt Q96QZ7 PFAM correlations Entrez Gene 9223 Kegg hsa:9223

References

UniProt :accession Q96QZ7