B melanoma antigen 4 (BAGE4 MLL3P)

Function: - known, candidate gene encoding tumor antigens Structure: belongs to the BAGE family Expression: - not expressed in normal tissues except in testis Pathology: expressed in melanoma, bladder & lung carcinomas Genetics: - ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene - the BAGE family was expanded by juxtacentromeric movement &/or acrocentric exchanges - BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 & 21 & of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 & 21

Properties

SIZE: MW = 4 kD entity length = 39 aa MOTIF: signal sequence {1-17}

Database Correlations

UniProt Q86Y28 Pfam PF08180

References

UniProt :accession Q86Y28