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BAF53 complex
Function:
- preferentially acetylates histone H4 (& H2A) within nucleosomes
Structure:
- subunits: ACTL6A/BAF53A, RUVBL1/TIP49, SMARCA2/BRM/BAF190B, & TRRAP/PAF400, & which may also include a HAT activity related to, but distinct from, that of KAT5
General
SWI/SNF-A (BAF) chromatin remodeling complex
Properties
COMPARTMENT: cell nucleus
SUBUNITS: actin-like protein 6A
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S233}
RuvB-like 1
COMPARTMENT: cell nucleus
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 70-77
global transcription activator SNF2L2
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S175}
glutamine-rich region {216-238}
MOTIF: glutamine residue (SEVERAL)
glutamine-rich region {245-253}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S329}
HSA {436-508}
arginine-rich region {559-562}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S591}
glutamate-rich region {643-650}
MOTIF: glutamate residue (SEVERAL)
helicase
NAME: helicase
SITE: 736-901
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 749-756
DEAD/H box
NAME: DEAD/H box
SITE: 851-854
Ser phosphorylation site {S956}
Helicase C-terminal {1054-1216}
glutamate-rich region {1297-1301}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1377}
Ser phosphorylation site {S1410}
Ser phosphorylation site {S1418}
bromodomain {1419-1489}
MOTIF: Ser phosphorylation site {S1419}
Ser phosphorylation site {S1512}
Ser phosphorylation site {S1516}
glutamate-rich region {1518-1529}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1528}
Ser phosphorylation site {S1568}
Ser phosphorylation site {S1572}
Ser phosphorylation site {S1582}
Ser phosphorylation site {S1585}
Thr phosphorylation site {T1587}
transformation/transcription domain-associated protein
MOTIF: proline-rich region
SITE: 485-526
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S1628}
TP53 interaction {2010-2388}
MOTIF: nuclear translocation signal {2047-2062}
Ser phosphorylation site {S2051}
Ser phosphorylation site {S2077}
Thr phosphorylation site {T2333}
Thr phosphorylation site {T2601}
FAT domain
NAME: FAT domain
SITE: 2704-3275
MOTIF: Tyr phosphorylation site
binding site
FOR-BINDING-OF: Paxillin
PI3K/PI4K {3528-3826}
FATC {3827-3859}
References
- UnitProt :accession P51531
- UniProt :accession O96019
Components
actin-like protein 6A; 53 kD BRG1-associated factor A; actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K (ACTL6A, BAF53, BAF53A, INO80K)
RuvB-like 1 (49-kD TATA box-binding protein-interacting protein, 49 kD TBP-interacting protein, TIP49a, Pontin 52, nuclear matrix protein 238, NMP 238, 54 kD erythrocyte cytosolic protein, ECP-54, TIP60-associated protein 54-alpha, TAP54-alpha, RUVBL1, NMP238, TIP49, TIP49A)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; global transcription activator SNF2L2; ATP-dependent helicase SMARCA2; SNF2-alpha; protein brahma homolog; hBRM; BRG1-associated factor 190B; BAF190B (SMARCA2, BAF190B, BRM, SNF2A, SNF2L2)
transformation/transcription domain-associated protein; 350/400 kD PCAF-associated factor; PAF350/400; STAF40; tra1 homolog (TRRAP, PAF400)