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bacitracin/polymixin-B (Polysporin, Ocumycin)

A combination of bacitracin + polymixin. Indications: - treat/prevent superficial bacterial skin infections due to susceptible gram (+) organisms - Staphylococcus, Streptococcus, anaerobic cocci, Corynebacterium, Clostridia) - treatment of eye infections - conjunctivits, keratoconjunctivitis, blepharitis, blepharoconjunctivitis, meibomitis, dacryocystitis, corneal ulcers [4] Contraindications: pregnancy-category C safety in lactation ? Dosage: Topical Agent: - Apply ointment/aerosol/powder 2-5 times/day. Ophthalmic agent: ointment every 3-4 hours or BID-QID Adverse effects: - not common (1-10%) - rash, itching, burning, anaphylactoid reactions, swelling, conjunctival erythema Mechanism of action: 1) inhibits bacterial cell wall synthesis 2) acts as a cationic detergent

General

antibiotic combination

References

  1. Department of Veterans Affairs, VA National Formulary
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Deprecated Reference

Components

bacitracin (AK-tracin) polymixin B (Aerosporin)