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transcription regulator protein BACH2 (BTB & CNC homolog 2, BACH2)
Function:
1) transcriptional regulator
2) acts as repressor or activator
3) binds to Maf recognition elements (MARE)
4) role in coordinating transcription activation & repression by MAFK
5) forms heterodimer with Maf-related transcription factors
Structure:
1) belongs to the bZIP family, CNC subfamily
2) contains 1 BTB domain (POZ domain)
3) contains 1 bZIP domain
Compartment: nucleus
Expression: B-cell specific
General
basic leucine zipper (bZIP) family protein
Properties
SIZE: MW = 93 kD
entity length = 841 aa
COMPARTMENT: cell nucleus
MOTIF: BTB domain {37-103}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
glutamate-rich region {162-169}
MOTIF: glutamate residue (SEVERAL)
DNA-binding motif
SITE: 651-666
leucine zipper
SITE: 674-695
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 605394
UniProt Q9BYV9
PFAM correlations
References
UniProt :accession Q9BYV9