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basic (brain) natriuretic peptide (BNP, B-type)

Function: - may function as a paracrine antifibrotic factor in the heart - role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, & inhibition of renin & aldosterone secretion - specifically binds & stimulates the cGMP production of the NPR1 receptor. - binds the clearance receptor NPR3 - mediates itch response in dorsal root ganglion cells expressing TRPV1 [4] - modulates ghrelin, hunger, & satiety in brain [6] Structure: - belongs to the natriuretic peptide family Compartment: secreted Expression: - brain - dorsal root ganglia - atria, but at much lower levels than ANP Pharmacology: - available under the name Nesiritide (scios), used for the treatment of heart failure

Related

B-type natriuretic peptide (BNP & N-terminal pro-BNP) in serum/plasma/blood BNP receptor; basic (brain) natriuretic peptide [BNP] receptor; atrial natriuretic peptide receptor B; ANP-B; ANPRB; GC-B; guanylate cyclase B; NPR-B; atrial natriuretic peptide B-type receptor (NPR2, ANPRB)

General

natriuretic hormone

Properties

COMPARTMENT: extracellular compartment SECRETED-BY: unspecified cell type WITHIN: brain unspecified cell type WITHIN: atrium unspecified cell type WITHIN: spinal ganglion MOTIF: cysteine residue {X} MODIFICATION: cysteine residue {X2} cysteine residue {X2} MODIFICATION: cysteine residue {X}

Database Correlations

OMIM 600295 UniProt P16860

References

  1. Ross CA, McInnis MG, Margolis RL, Li SH. Genes with triplet repeats: candidate mediators of neuropsychiatric disorders. Trends Neurosci. 1993 Jul;16(7):254-60. Review. PMID: 7689767
  2. Journal Watch 21(7):56, 2001 Dao Q, Krishnaswamy P, Kazanegra R, Harrison A, Amirnovin R, Lenert L, Clopton P, Alberto J, Hlavin P, Maisel AS. Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting. J Am Coll Cardiol. 2001 Feb;37(2):379-85. PMID: 11216950, 2001
  3. Journal Watch 21(22):178, 2001 de Lemos JA, Morrow DA, Bentley JH, Omland T, Sabatine MS, McCabe CH, Hall C, Cannon CP, Braunwald E. The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med. 2001 Oct 4;345(14):1014-21. PMID: 11586953
  4. Mishra SK, Hoon MA. The cells and circuitry for itch responses in mice. Science 2013 May 24; 340:968 PMID: 23704570
  5. Wikipedia: Brain natriuretic peptide http://en.wikipedia.org/wiki/brain_natriuretic_peptide
  6. Vila G, Grimm G, Resl M et al B-type natriuretic peptide modulates ghrelin, hunger, and satiety in healthy men. Diabetes [2012, 61(10):2592-2596] PMID:22698919