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B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL)
See chronic lymphocytic leukemia.
Microscopic pathology:
- small lymphocytes
- some may show plasmacytoid differentiation
Immunophenotype:
- surface IgM weak/IgM +
- IgD +
- CD5 +
- CD10 -
- CD11c weak
- CD19 +
- CD20 weak
- CD22 weak
- CD23 +/-
- CD43 +
- CD79a +
- CD79b -/weak
- cyclin D1 -
- FMC7 -/weak
Genetics:
- chromosomal translocation t(11;19)(q13;p13) involving FSTL3 with CCDN1 is found in a case of B-cell chronic lymphocytic leukemia
- translocation t(14;19)(q32;q13.1) involving BCL3 with immunoglobulin gene regions is associated with B-CLL
- chromosomal translocation t(X;11)(q21;q23) involving BRWD3 with ARHGAP20, does not result in fusion transcripts but disrupts both genes
- BRWD3 is down-regulated in a majority of the B-cell CLL cases
- may be associated with defects in ATM gene
- chromosomal translocation t(8;12)(q24;q22) involving MYC with BTG1 may be a cause of B-cell chronic lymphocytic leukemia
Interactions
disease interactions
General
chronic lymphocytic leukemia (CLL)
peripheral B-cell lymphoid neoplasm
small lymphocytic lymphoma
Database Correlations
OMIM correlations
References
- WHO Classification Tumours of Haematopoietic and Lymphoid
Tissues. IARC Press 2001