melanocortin 2 receptor accessory protein (fat cell-specific low molecular weight protein, fat tissue-specific low MW protein, B27, MRAP, C21orf61, FALP)

Function: 1) required for MC2R expression in certain cell types 2) role in processing, trafficking or function of MC2R (putative) 3) role in intracellular trafficking pathways in adipocytes 4) interacts with MC2R. Compartment: - cytoplasm, perinuclear region, cell membrane, endoplasmic reticulum - concentrated at perinuclear membrane region - upon insulin stimulation, redistributed into spotty structures throughout cytoplasm - localizes both to plasma membrane & endoplasmic reticulum Alternative splicing: named isoforms=4 Expression: - expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary, fat - expressed in adipose tissues Pathology: - defects in MRAP are a cause of familial glucocorticoid deficiency type 1

Properties

SIZE: MW = 19 kD entity length = 172 aa COMPARTMENT: cytoplasm nuclear membrane endoplasmic reticulum MOTIF: transmembrane domain {38-58}

Database Correlations

OMIM 202200 UniProt Q8TCY5

References

UniProt :accession Q8TCY5