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avibactam/ceftazidime (Avycaz)

Indications: - complicated intra-abdominal infections - Avycaz used with metronidazole - complicated urinary tract infections Contraindications: - caution in patients with renal impairment Dosage: - 2.5 g IV every 8 hours - infuse over 2 hours - 5-14 days of therapy Vials contain Avycaz 2.5 gram, equivalent to ceftazidime 2 gram & avibactam 0.5 gram [3] Dosage adjustment in renal failure: - 1.25 g every 8 hours for CrCl of 31-50 mL/min - 0.94 g every 12 hours for CrCl of 16 to 30 mL/min - 0.94 g every 24 hours for CrCl of 6 to 15 mL/min - 0.94 g every 48 hours for CrCl < 6 mL/min Adverse effects: - anxiety, constipation, nausea, vomiting - seizures may occur in patients with renal impairment - Stevens-Johnson syndrome, toxic epidermal necrolysis & anaphylaxis may occur in patients with penicillin allergies [1] Mechanism of action: - cephalosporin, beta-lactamase inhibitor combination Notes: - distributed by Forest Pharmaceuticals Inc

General

antibiotic combination

References

  1. Kelley KJ, Sofair A, Chavey WE New Combo Antibacterial Approved for Complicated Intra-Abdominal Infections, UTIs Physician's First Watch, Feb 27, 2015 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - FDA News Release. February 25, 2015 FDA approves new antibacterial drug Avycaz http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm435629.htm
  2. Prescriber's Letter 23(3): 2015 New Drug: Avycaz (Ceftazidime/Avibactam) Detail-Document#: 310525 (subscription needed) http://www.prescribersletter.com
  3. FDA Safety Alert. Sept 22, 2015 Avycaz (ceftazidime and avibactam): Drug Safety Communication - Dose Confusion and Medication Errors http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm463595.htm

Components

avibactam ceftazidime (Fortaz, Tazidime, Tazicef)