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avanafil (Stendra)
Indications:
- treatment of erectile dysfunction
Contraindications:
- creatinine clearance < 30 ml/min
- liver failure
Dosage::
- 50-200 mg 30 minutes prior to sexual activity
Pharmacokinetics:
- duration of about 5 hours, similar to Viagra, Levitra
Adverse effects:
- headache, back pain, flushing, headache, nasal congestion, pharygitis
- priapism (rare)
Drug interactions:
- hypotension in combination with nitrates
- prone to CYP3A4 interactions [2]
- avoid it with strong inducers of CYP3A4 (phenytoin) or strong inhibitors (itraconazole)
Interactions
drug adverse effects of phosphodiesterase-5-inhibitors
General
phosphodiesterase-5 inhibitor
References
- FDA News Release: April 27, 2012
FDA approves Stendra for erectile dysfunction
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm302140.htm
- Prescriber's Letter 21(4): 2014
Comparison of PDE5 Inhibitors
Detail-Document#: 300408
(subscription needed) http://www.prescribersletter.com