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tazarotene (Tazorac, Avage, Zorac)
Tradename: Tazorac.
Indications:
- psoriasis
- acne
- wrinkles
- hyperpigmentation, hypopigmentation [3]
- lentigo [3]
Contraindications:
1) women who may become pregnant
2) do not use on eczematous skin
Dosage: apply QD-BID
Tazorac: 0.05%, 0.1% topical gel: 30 g, 100 g.
Avage: 0.1%
Adverse effects:
1) common (> 10%)
- pruritus, burning, stinging, erythema, worsening of psoriasis, irritation, skin pain
2) less common (1-10%)
- rash, desquamation, irritant contact dermatitis, skin inflammation, fissuring, bleeding & dry skin, localized edema, skin discoloration
3) other
- increased susceptiblity to sunburn (use sunscreen & protective clothing)
Drug interactions:
1) avoid concurrent use of photosensitizers:
- tetracyclines, thiazides, fluoroquinolones, phenothiazines, sulfonamides
2) concurrent use of dermatologic medications & cosmetics that have a drying effect should be avoided
Mechanism of action:
-> retinoid
a) all retinoids reduce fine wrinkles, rough skin, brown spots
b) wrinkles reappear when retinoid is stopped
c) activates RARRES2 in psoriatic lesions
General
retinoid
Properties
MISC-INFO: pregnancy-category X
Database Correlations
PUBCHEM cid=5381
References
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Prescriber's Letter 10(1):5 2003
- Deprecated Reference