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Auer rod

Etiology: - Auer rods can be found in any of the subtypes of AML, but they are especially with - AML M1 (acute myleloid leukemia) - AML M3 (acute promyelocytic leukemia) Pathology: - Auer rods are linear or spindle-shaped red-purple inclusion in myeloblasts or promyelocytes stained with Romanowsky stain. - Less commonly, they may be seen in more mature neutrophils. - Their presence is pathognomonic for the diagnosis - acute myleloid leukemia (AML) or - refractory anemia with excess blasts in transformation - Auer rods are derivatives of azurophilic granules & stain positively for Sudan Black B, myeloperoxidase, ASD chloroacetate esterase, & acid phosphatase

General

abnormal morphologic structure (malformation)

Properties

PATHOLOGY: acute myeloid leukemia (AML)

References

  1. Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 692