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atypical ductal hyperplasia of breast

Epidemiology: - 100,000 women per year in the U.S [3] Radiology: - stereotactic biopsy of suspicious microcalcifications identified at mammography Complications: - 3-5 fold increased risk of breast cancer - cumulative incidence of breast cancer at 30 years is 35% [1,2] - 10 year risk for invasive breast cancer after diagnosis is 5.0-6.7% [3] Differential diagnosis: - ductal adenocarcinoma Management: - exemestane reduces risk of breast cancer in post-menopausal women with atypical ductal hyperplasia [1,2]

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ductal adenocarcinoma

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ductal hyperplasia

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 17, 19. American College of Physicians, Philadelphia 2015, 2021.
  2. Goss PE et al Exemestane for Breast-Cancer Prevention in Postmenopausal Women N Engl J Med. 2011 Jun 23;364(25):2381-91. Epub 2011 Jun 4. PMID: 21639806
  3. Menes TS et al. Subsequent breast cancer risk following diagnosis of atypical ductal hyperplasia on needle biopsy. JAMA Oncol 2016 Sep 8; PMID: 27607465 - Howard-McNatt M. Atypical ductal hyperplasia: What is the current risk for developing breast cancer? JAMA Oncol 2016 Sep 8; PMID: 27606772