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atypical chemokine receptor; chemokine-scavenging receptor; chemokine decoy receptor
Fuunction:
- controls chemokine levels & localization via high-affinity chemokine binding uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis
- also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor
- acts as a receptor for chemokines
- chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization
Specific
atypical chemokine receptor 2; C-C chemokine receptor 10; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine receptor CCR-9; chemokine-binding protein 2; chemokine-binding protein D6 (ACKR2, CCBP2, CCR10, CMKBR9, D6)
atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1 (ACKR3, CMKOR1, CXCR7, GPR159, RDC1)
atypical chemokine receptor 4; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCRL1; CCX CKR (ACKR4, CCBP2, CCR11, CCRL1 ,VSHK1)
General
chemokine receptor (chemoattractant receptor)
G-protein coupled receptor; serpentine receptor
Properties
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {N-TERMINAL}
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
binding site
SITE: C-TERMINAL-CYS
EFFECTOR-BOUND: palmitate
BOUND-VIA: carboxylate
cysteine residue
box1 motif
FOR-BINDING-OF: Janus kinase (JAK)
box2 motif
FOR-BINDING-OF: Janus kinase (JAK)
Tyr phosphorylation site
cytoplasmic domain {C-TERMINAL}
References
- UniProt :accession O00590
- UniProt :accession Q9NPB9