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attapulgite (Kaopectate)

Tradename: Kaopectate* * has been reformulated to contain bismuth subsalicylate [3] Indication: adjunctive therapy for management of diarrhea Dosage: - 30 mg PO after each loose bowel movement - up to 7 doses/day. - 15 mL/dose if 6-12 yo - 7.5 mL/dose if 3-5 yo. Liquid: 600 mg/15 mL Elimination: Not absorbed. Mechanism of action: 1) decreases intestinal motility 2) enhances absorption of intestinal fluid 3) eventually to be withdrawn from market due to lack of effectiveness [3]

General

anti-motility agent; antiperistaltic agent

Properties

MISC-INFO: elimination route FECES pregnancy-category + safety in lactation +

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
  3. Prescriber's Letter 10(4):24 2003

Component-of

atropine/attapulgite/hyoscyamine/scopolamine (Donnagel) attapulgite/bismuth subsalicylate/kaolin/pectin (Kaopectate)