F-box only protein 32; muscle atrophy F-box protein; MAFbx; atrogin-1 (FBXO32)

Function: - substrate recognition component of SKP1-CUL1-F-box protein (SCF) complex, an E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins - probably recognizes & binds to phosphorylated target proteins during skeletal muscle atrophy - recognizes TERF1 protein modification; protein ubiquitination Structure: contains 1 F-box domain Expression: - specifically expressed in cardiac & skeletal muscle Pathology: - upregulated with muscle atrophy

Properties

SIZE: entity length = 355 aa MW = 42 kD MOTIF: F-box domain {223-271}

Database Correlations

OMIM 606604 UniProt Q969P5 Entrez Gene 114907 Kegg hsa:114907

References

UniProt :accession Q969P5