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atrial natriuretic factor/peptide/hormone (ANF/ANP/ANH) in plasma

Normal range: - 20-77 pg/mL Clinical significance: - high ANP or BNP is associated with increased risk of major cardiovascular event - high level of either peptide also predicts increased risk for heart failure & atrial fibrillation [2] Increases: 1) congestive heart failure 2) cardiovascular disease with elevated cardiac filling pressure 3) cardiac volume overload 4) atrial pacing 5) paroxysmal atrial tachycardia Decreases: -> chemical interferences -> prazosin, urapidil, xipamide Specimen: 1) plasma (K2EDTA) 2) collect blood into pre-chilled tubes & deliver to the lab on ice 3) centrifuge in a refrigerated centrifuge & freeze plasma promptly 4) stable for 4 weeks at -25 degrees C

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atrial natriuretic factor/peptide (ANF, ANP)

General

atrial natriuretic factor/peptide/hormone (ANF/ANP/ANH) in blood/plasma

References

  1. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  2. Journal Watch 24(5):38, 2004 Wang TJ et al, N Engl J Med 350:655, 2004 PMID: 14960742