atrial natriuretic factor/peptide (ANF, ANP)

Function: - endogenous anti-hypertensive agent secreted from the cardiac atria - derived from a larger precursor protein (NPPA) Mechanism of action: 1) enhances salt & water excretion 2) blocks aldosterone & renin secretion 3) inhibits the action of angiotensin II & vasopressin 4) inhibits smooth muscle contraction 5) net effect is a decrease in blood pressure & blood volume

Related

ANP receptor-C; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide C-type receptor; ANPRC; ANP-C; NPR-C (NPR3 ANPRC) atrial natriuretic factor/peptide/hormone (ANF/ANP/ANH) in plasma atrial natriuretic peptide receptor A; atrial natriuretic peptide A-type receptor; ANPRA; ANP-A; NPR-A; guanylate cyclase; GC-A (NPR1, ANPRA)

General

natriuretic hormone natriuretic peptides A; CDD-ANF; prepronatriodilatin; contains: cardiodilatin-related peptide; CDP; contains: atrial natriuretic factor; ANF; atrial natriuretic peptide; ANP (NPPA, PND)

Properties

SIZE: entity length = 153 aa MW = 17 kD COMPARTMENT: extracellular compartment MOTIF: cysteine residue {X2} MODIFICATION: cysteine residue {X} signal sequence {1-25} cysteine residue {X} MODIFICATION: cysteine residue {X2} proteolytic site {123-124} cysteine residue {C130} MODIFICATION: cysteine residue {C146} cysteine residue {C146} MODIFICATION: cysteine residue {C130}

References

Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995