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ATP-sensitive K+ channel (inwardly-rectifying K+ channel)

Function: - inwardly rectifying K+ channel - phosphorylation & subsequent ATP-binding close channel, depolarizing beta cell - depolarization of beta cell linked to Ca+2 influx & insulin secretion Structure: - Structure: - between the two transmembrane domains is an exoplasmic loop (H5 region) containing the pore-forming region

Interactions

molecular events

Specific

ATP-sensitive inward rectifier K+ channel 12; K+ channel, inwardly rectifying subfamily J member 12; Inward rectifier K+ channel Kir2.2; Kir2.2v; IRK2 (KCNJ12, IRK2, KCNJN1) ATP-sensitive inward rectifier K+ channel 15; K+ channel, inwardly rectifying subfamily J member 15; inward rectifier K+ channel Kir4.2; Kir1.3 (KCNJ15 KCNJ14) inwardly-rectifying K+ channel J10; ATP-sensitive inward rectifier K+ channel 10; K+ channel, inwardly rectifying subfamily J member 10; inward rectifier K+ channel Kir1.2; ATP-dependent inwardly rectifying K+ channel Kir4.1 (KCNJ10) inwardly-rectifying K+ channel J11; ATP-sensitive inward rectifier K+ channel 11; K+ channel, inwardly rectifying subfamily J member 11; inward rectifier K+ channel Kir6.2; IKATP (KCNJ11) inwardly-rectifying K+ channel J1; ATP-sensitive inward rectifier K+ channel 1; K+ channel, inwardly rectifying subfamily J member 1; ATP-regulated K+ channel ROM-K; Kir1.1 (KCNJ1, ROMK1) inwardly-rectifying K+ channel J8; ATP-sensitive inward rectifier K+ channel 8; K+ channel, inwardly rectifying subfamily J member 8; inwardly rectifier K+ channel Kir6.1; uKATP-1 (KCNJ8)

General

inwardly-rectifying K+ channel phosphoprotein

Properties

COMPARTMENT: plasma membrane CELL: beta cell WITHIN: islets of Langerhans ORGANISM: vertebrate* MOTIF: Ser phosphorylation site {S4} Thr phosphorylation site {T17} Ser phosphorylation site {S44} transmembrane domain N-glycosylation site H5 (K+) pore-forming region transmembrane domain Ser phosphorylation site {S183} Thr phosphorylation site {T191} Thr phosphorylation site {T193} Ser phosphorylation site {S201} Ser phosphorylation site {S219} ATP-binding site NAME: ATP-binding site Thr phosphorylation site {T234} Ser phosphorylation site {S313} ION-PERMEABILITY: K+

References

  1. Holz GG, Habener JF. Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Trends Biochem Sci. 1992 Oct;17(10):388-93. Review. PMID: 1455507
  2. Ho K, Nichols CG, Lederer WJ, Lytton J, Vassilev PM, Kanazirska MV, Hebert SC. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature. 1993 Mar 4;362(6415):31-8. PMID: 7680431

Components

sulfonylurea receptor 1; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette C8 (ABCC8, HRINS, SUR SUR1) sulfonylurea receptor 2; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette C9 (ABCC9, SUR2)