ATP-binding site or Rossmann motif

The best conserved sequence of ATP/GTP binding motifs is a glycine-rich region, which forms a flexible loop between a beta-strand & an alpha-helix. This loop interacts with one of the phosphates of the nucleotide, thus the name 'P-loop'. Not all ATP- or GTP-binding proteins seem to contain a P-loop. Some proteins contain a completely unrelated ATP-binding site. Other ATP- or GTP-binding proteins contain a flexible loop in a slightly different form than the P-loop.

Specific

AMP-binding domain ATP-grasp domain NACHT-NTPase domain P-loop Tudor domain

General

adenine nucleotide-binding site Mg+2-binding site

Properties

NAME: ATP-binding site MISC-INFO: consensus

References

prosite :accession PS00017