Na+/K+ ATPase-alpha 2; Na+ pump subunit alpha-2; Na+/K+ ATPase alpha-2 subunit (ATP1A2, KIAA0778)

Function: - catalytic component of the active Na⁺/K⁺ ATPase, which catalyzes hydrolysis of ATP coupled with exchange of Na⁺ & K⁺ ions across the plasma membrane - this action creates the electrochemical gradient of Na⁺ & K⁺, providing the energy for active transport of various nutrients Structure: - belongs to the cation transport ATPase (P-type) family, type IIC subfamily Compartment: membrane Expression: - predominant in neural & muscle tissues Pathology: - defects in ATP1A2 are the cause of familial hemiplegic migraine 2 - defects in ATP1A2 are a cause of alternating hemiplegia of childhood

Related

ATP1A2 gene mutation Na+/K+ ATPase

General

Na+/K+ ATPase-alpha phosphoprotein transmembrane 10 protein

Properties

SIZE: entity length = 1020 aa MW = 112 kD MOTIF: cytoplasmic domain {6-85} MOTIF: phosphoinositide-3 kinase interaction {80-82} transmembrane domain {86-106} exoplasmic loop {107-129} transmembrane domain {130-150} cytoplasmic loop {151-286} transmembrane domain {287-306} exoplasmic loop {307-318} transmembrane domain {319-336} cytoplasmic loop {337-769} MOTIF: aspartate residue {D374} Ser phosphorylation site {S650} Mg+2-binding site SITE: 714-714 Mg+2-binding site SITE: 718-718 transmembrane domain {770-789} exoplasmic loop {790-799} transmembrane domain {800-820} cytoplasmic loop {821-840} transmembrane domain {841-863} exoplasmic loop {864-915} transmembrane domain {916-935} cytoplasmic loop {936-948} MOTIF: Ser phosphorylation site {S940} transmembrane domain {949-967} exoplasmic loop {968-982} transmembrane domain {983-1003} cytoplasmic domain {1004-1020}

Database Correlations

OMIM correlations MORBIDMAP 182340 UniProt P50993 PFAM correlations Entrez Gene 477 ENZYME 3.6.3.9