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activating transcription factor 7; cyclic AMP-dependent transcription factor ATF-7; transcription factor ATF-A (ATF7, ATFA)
Function:
- binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral & cellular promoters
- binds DNA as a dimer
Structure:
- belongs to the bZIP family
- contains 1 bZIP domain
- contains 1 C2H2-type Zn+2 finger
Compartment: nucleus
Alternative splicing: named isoforms=3
General
activating transcription factor
phosphoprotein
Properties
SIZE: entity length = 494 aa
MW = 53 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 7-31
EFFECTOR-BOUND: Zn+2
Thr phosphorylation site {T51}
Thr phosphorylation site {T53}
Ser phosphorylation site {S111}
Thr phosphorylation site {T112}
Ser phosphorylation site {S127}
Ser phosphorylation site {S128}
Ser phosphorylation site {S132}
Ser phosphorylation site {S135}
Ser phosphorylation site {S136}
Ser phosphorylation site {S139}
DNA-binding motif
SITE: 342-365
leucine zipper
SITE: 371-399
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 606371
UniProt P17544
PFAM correlations
Entrez Gene 11016
Kegg hsa:1101
References
- UniProt :accession P17544
- Entrez Gene :accession 11016