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activating transcription factor-4; cyclic AMP-dependent transcription factor ATF-4; DNA-binding protein TAXREB67; cyclic AMP response element-binding protein 2; CREB2 (ATF4, TXREB)
Function:
- transcriptional activator
- binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral & cellular promoters
- binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I
- interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain
- interacts with the C-terminal region of GABBR2 (putative)
- binds DNA as a homodimer or heterodimer
- interacts with the N-terminal region of CEP290
Structure:
- belongs to the bZIP family
- contains 1 bZIP domain
Compartment:
- cytoplasm, cell membrane, nucleus
- colocalizes with GABBR1 in hippocampal neuron dendritic membranes (putative)
Comparative biology:
- ortholog of yeast GCN-4
- elevation of ATF4 expression, at least in liver, seems to be a shared feature of diets, drugs, genes, & developmental alterations that extend maximum lifespan in mice [3]
General
activating transcription factor
Properties
SIZE: entity length = 351 aa
MW = 39 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: basic region
coiled coil {280-340}
MOTIF: DNA-binding motif
SITE: 280-300
GABBR1 interaction {305-341}
MOTIF: leucine zipper
SITE: 306-334
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 604064
UniProt P18848
Pfam PF00170
Entrez Gene 468
Kegg hsa:468
References
- UniProt :accession P18848
- Entrez Gene :accession 468
- Li W, Li X, Miller RA.
ATF4 activity: a common feature shared by many kinds of
slow-aging mice.
Aging Cell. 2014 Dec;13(6):1012-8.
PMID: 25156122 Free PMC Article