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activating transcription factor-3; cyclic AMP-dependent transcription factor (ATF-3, ATF3)
Function:
- binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral & cellular promoters
- represses transcription from promoters with ATF sites
- may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter
- isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters
- binds DNA as a homodimer or a heterodimer
Structure:
- belongs to the bZIP family, ATF subfamily
- contains 1 bZIP domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Note:
- may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
General
activating transcription factor
Properties
SIZE: entity length = 181 aa
MW = 21 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 88-110
leucine zipper
SITE: 114-142
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 603148
UniProt P18847
Pfam PF07716
Entrez Gene 467
Kegg hsa:467
References
- UniProt :accession P18847
- Entrez Gene :accession 467