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activating transcription factor-1; cyclic AMP-dependent transcription factor ATF-1; TREB36 protein (ATF1)

Forms heterodimer with CREB. Function: - binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral & cellular promoters - binds to the Tax-responsive element (TRE) of HTLV-I - mediates PKA-induced stimulation of CRE-reporter genes - binds DNA as a dimer Structure: - belongs to the bZIP family, ATF subfamily - contains 1 bZIP domain - contains 1 KID (kinase-inducible) domain Compartment: nucleus

Related

ATF1 gene

General

activating transcription factor

Properties

SIZE: entity length = 271 aa MW = 29 kD COMPARTMENT: cell nucleus MOTIF: KID {31-90} MOTIF: Ser phosphorylation site {S63} DNA-binding motif SITE: 215-235 leucine zipper SITE: 241-262 FOR-BINDING-VIA: leucine zipper

Database Correlations

OMIM 123803 UniProt P18846 PFAM correlations Entrez Gene 466 Kegg hsa:466

References

  1. Hoeffler JP, Lustbader JW, Chen CY. Identification of multiple nuclear factors that interact with cyclic adenosine 3',5'-monophosphate response element-binding protein and activating transcription factor-2 by protein- protein interactions. Mol Endocrinol. 1991 Feb;5(2):256-66. PMID: 1828107
  2. Entrez Gene :accession 466
  3. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/ATF1ID81.html
  4. UniProt :accession P18846