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polycomb group protein ASXL1 (additional sex combs-like protein 1, ASXL1, KIAA0978)
Function: polycomb group protein
Structure:
- belongs to the Asx family.
- contains 1 PHD-type zinc finger
- contains 1 LXXLL motif (Leu-Xaa-Xaa-Leu-Leu), which may be required for an association with nuclear receptors
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- widely expressed at low level
- expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow, fetal liver
- highly expressed in testes
Laboratory:
- ASXL1 genotyping
General
zinc finger protein
Properties
SIZE: MW = 165 kD
entity length = 1541 aa
COMPARTMENT: cell nucleus
MOTIF: lysine-rich region {2-9}
MOTIF: lysine residue (SEVERAL)
nuclear translocation signal {160-164}
serine-rich region {199-209}
MOTIF: serine residue (SEVERAL)
LXXLL {284-288}
nuclear translocation signal {409-413}
Ser phosphorylation site {S503}
glycine-rich region {641-684}
serine-rich region {1457-1460}
MOTIF: serine residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1503-1540
EFFECTOR-BOUND: Zn+2
Database Correlations
UniProt Q8IXJ9
References
UniProt :accession Q8IXJ9