asporin (periodontal ligament-associated protein 1, PLAP-1, ASPN, PLAP1, UNQ215/PRO241)

Structure: - belongs to the small leucine-rich proteoglycan (SLRP) family, class I subfamily - contains 12 LRR repeats (leucine-rich repeats_ - no Ser/Gly dipeptide sequence expected for attachment of O-linked glycosaminoglycans, thus probably not a proteoglycan - O-linked polysaccharide on 54-Ser is probably mucin type linked to GalNAc - N-linked glycan at Asn-281 consists of variable structures of GlcNAc, mannose, fucose, HexNAc & hexose Compartment: extracellular matrix Expression: - expressed in aorta, uterus > small intestine, heart, liver, bladder, ovary, stomach, adrenal, thyroid, mammary glands > trachea, bone marrow, lung Pathology: - high expression in osteoarthritic articular cartilage Polymorphism: - poly-Asp region of ASPN is polymorphic, ranges at least from 11-17 Asp

Properties

SIZE: MW = 43 kD entity length = 379 aa COMPARTMENT: extracellular matrix MOTIF: signal sequence {1-14} Ser glycosylation site {S54} cysteine-rich region {76-89} leucine-rich repeat SITE: 95-115 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 116-139 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 140-163 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 164-184 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 185-208 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 209-233 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 234-254 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 255-278 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 279-302 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N281} leucine-rich repeat SITE: 303-325 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 326-355 MOTIF: leucine residue (SEVERAL) cysteine residue {C332} MODIFICATION: cysteine residue {C365} leucine-rich repeat SITE: 356-379 MOTIF: leucine residue (SEVERAL) cysteine residue {C365} MODIFICATION: cysteine residue {C332}

Database Correlations

OMIM 608135 UniProt Q9BXN1 PFAM correlations

References

UniProt :accession Q9BXN1