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abnormal spindle-like microcephaly-associated protein (abnormal spindle protein homolog, Asp homolog, ASPM MCPH5)
Function:
1) role in mitotic spindle regulation (putative)
2) coordination of mitotic processes
3) role in regulating neurogenesis
Structure:
- contains 2 CH doamins (calponin-homology domains)
- contains 39 IQ domains
Compartment:
- cytoplasm, nucleus
- nuclear-cytoplasmic distribution may be regulated by calmodulin
Alternative splicing: named isoforms=2
Pathology:
- defects in ASPM are associated with primary microcephaly 5
General
phosphoprotein
Properties
SIZE: MW = 410 kD
entity length = 3477 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S14}
Ser phosphorylation site {S35}
Ser phosphorylation site {S222}
Ser phosphorylation site {S225}
Ser phosphorylation site {S263}
Ser phosphorylation site {S267}
Ser phosphorylation site {S270}
Ser phosphorylation site {S280}
Ser phosphorylation site {S283}
Ser phosphorylation site {S348}
Ser phosphorylation site {S367}
Ser phosphorylation site {S370}
Ser phosphorylation site {S392}
Ser phosphorylation site {S425}
Ser phosphorylation site {S463}
Thr phosphorylation site {T563}
Ser phosphorylation site {S605}
Thr phosphorylation site {T647}
calponin homology domain
NAME: calponin homology domain
SITE: 920-1056
coiled coil {1057-1078}
Ser phosphorylation site {S1103}
calponin homology domain
NAME: calponin homology domain (39)
SITE: 1110-3235
Thr phosphorylation site {T3435}
Database Correlations
OMIM correlations
UniProt Q8IZT6
PFAM correlations
References
UniProt :accession Q8IZT6