aspartate aminotransferase (AST), glutamine/oxaloacetate transaminase (GOT, SGOT) or transaminase A

Function: - interconverts aspartate & oxalate Expression: - present in many tissues: heart > liver > skeletal muscle > kidney > brain > pancreas > spleen > lung Laboratory: - see AST in serum - serum AST diminished in pregnancy - aspartate aminotransferase in body fluid - aspartate aminotransferase in amniotic fluid - aspartate aminotransferase in dialysis fluid - aspartate aminotransferase in gastric fluid - aspartate aminotransferase in peritoneal fluid - aspartate aminotransferase in pleural fluid - aspartate aminotransferase in serum - aspartate aminotransferase in synovial fluid - aspartate aminotransferase in urine - aspartate aminotransferase in erythrocytes Compatative biology: - in eukaryotes there are cytoplasmic, mitochondrial & chloroplastic isozymes

Specific

cytoplasmic aspartate aminotransferase (GOT1, transaminase A) mitochondrial aspartate aminotransferase (glutamate oxaloacetate transaminase 2, mAspAT, fatty acid-binding protein, FABP-1, FABPpm, GOT2, AST2)

Properties

MOTIF: cofactor-binding site COFACTOR-BOUND: pyridoxal phosphate MISC-INFO: lifetime 12-22 HOURS {1/2-LIFE}

References

Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 264