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Achaete-scute homolog 2; ASH-2; hASH2; mash2; class A basic helix-loop-helix protein 45; bHLHa45 (ASCL2, BHLHA45 HASH2)
Function:
- AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system & the central nervous system
- efficient DNA binding requires dimerization with another bHLH protein
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
Compartment:
- nucleus
Expression:
- expressed specifically in the extravillous trophoblasts of the developing placenta
Related
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein, ASH2L)
General
achaete scute homolog
Properties
SIZE: entity length = 193 aa
MW = 20 kD
COMPARTMENT: cell nucleus
MOTIF: arginine-rich region {36-39}
MOTIF: arginine residue (SEVERAL)
DNA-binding motif
SITE: 53-63
helix-loop-helix
NAME: helix-loop-helix
SITE: 64-103
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 601886
UniProt Q99929
Pfam PF00010
Entrez Gene 430
Kegg hsa:430
References
- UniProt :accession Q99929
- ) Entrez Gene :accession 430
Component-of
histone H3-specific methyltransferase complex