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asialoglycoprotein receptor 2; ASGP-R 2; ASGPR 2; hepatic lectin H2 (ASGR2)
Function:
- mediates endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed (asialoglycoprotein)
- the receptor recognizes terminal galactose & N-acetylgalactosamine units
- Ca+2 is required for ligand binding
- after ligand binding, the receptor-ligand complex is internalized & transported to a sorting organelle, where receptor & ligand are disassociated
- the receptor then returns to the cell membrane surface
- the functioning ligand-binding unit of this receptor is thought to be at least a dimer
- interacts with LASS2
Structure: contains 1 C-type lectin domain
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- expressed exclusively in hepatic parenchymal cells
General
asialoglycoprotein receptor
Ca+2 binding protein
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 311 aa
MW = 35 kD
COMPARTMENT: cellular membrane
MOTIF: Endocytosis signal {5-8}
Ser phosphorylation site {S13}
cysteine residue {C54}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {59-79}
N-glycosylation site {N102}
N-glycosylation site {N170}
C-type lectin {176-302}
MOTIF: cysteine residue {C177}
MODIFICATION: cysteine residue {C188}
cysteine residue {C188}
MODIFICATION: cysteine residue {C177}
cysteine residue {C205}
MODIFICATION: cysteine residue {C300}
cysteine residue {C278}
MODIFICATION: cysteine residue {C292}
cysteine residue {C292}
MODIFICATION: cysteine residue {C278}
cysteine residue {C300}
MODIFICATION: cysteine residue {C205}
N-glycosylation site {N305}
Database Correlations
OMIM 108361
UniProt P07307
PFAM correlations
Entrez Gene 433
Kegg hsa:433
References
- UniProt :accession P07307
- Functional glycomics gateway - glycan binding
Note: hepatic asialoglycoprotein receptor subunit 2
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_216