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asialoglycoprotein receptor 1; ASGP-R 1; ASGPR 1; hepatic lectin H1 (ASGR1)
Function:
- mediates endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed (asialoglycoprotein)
- receptor recognizes terminal galactose & N-acetylgalactosamine units
- Ca+2 is required for ligand binding
- after ligand binding, the receptor-ligand complex is internalized & transported to a sorting organelle, where receptor & ligand are disassociated
- the receptor then returns to the cell membrane surface
- interacts with LASS2
- phosphorylated on a cytoplasmic Ser
Structure: contains 1 C-type lectin domain
Compartment: membrane
Expression:
- expressed exclusively in hepatic parenchymal cells
Pathology:
- plasma ASGR1 associated with loneliness [3]
General
asialoglycoprotein receptor
Ca+2 binding protein
glycoprotein
Properties
SIZE: entity length = 291 aa
MW = 33 kD
COMPARTMENT: cellular membrane
MOTIF: Endocytosis signal {5-8}
cysteine residue {C36}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {41-61}
coiled coil {61-123}
MOTIF: N-glycosylation site {N79}
N-glycosylation site {N147}
cysteine residue {C154}
MODIFICATION: cysteine residue {C165}
C-type lectin {161-278}
MOTIF: cysteine residue {C165}
MODIFICATION: cysteine residue {C154}
cysteine residue {C182}
MODIFICATION: cysteine residue {C277}
Ca+2-binding site
SITE: 191-191
Ca+2-binding site
SITE: 197-197
Ca+2-binding site
SITE: 216-216
Ca+2-binding site
SITE: 240-240
binding site
SITE: 240-240
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 242-242
Ca+2-binding site
SITE: 243-243
binding site
SITE: 244-244
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 253-253
binding site
SITE: 253-253
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 254-254
cysteine residue {C255}
MODIFICATION: cysteine residue {C269}
Ca+2-binding site
SITE: 265-265
Ca+2-binding site
SITE: 266-266
cysteine residue {C269}
MODIFICATION: cysteine residue {C255}
cysteine residue {C277}
MODIFICATION: cysteine residue {C182}
Ca+2-binding site
SITE: 278-278
Database Correlations
OMIM 108360
UniProt P07306
PFAM correlations
Entrez Gene 432
Kegg hsa:432
References
- UniProt :accession P07306
- Functional glycomics gateway - glycan binding
Note: hepatic asialoglycoprotein receptor subunit 1
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_215
- Shen C, Zhang R, Yu J, Sahakian BJ, Cheng W, Feng J.
Plasma proteomic signatures of social isolation and loneliness associated
with morbidity and mortality.
Nat Hum Behav. 2025 Jan 3.
PMID: 39753750