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asialoglycoprotein receptor 1; ASGP-R 1; ASGPR 1; hepatic lectin H1 (ASGR1)
Function:
- mediates endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed (asialoglycoprotein)
- receptor recognizes terminal galactose & N-acetylgalactosamine units
- Ca+2 is required for ligand binding
- after ligand binding, the receptor-ligand complex is internalized & transported to a sorting organelle, where receptor & ligand are disassociated
- the receptor then returns to the cell membrane surface
- interacts with LASS2
- phosphorylated on a cytoplasmic Ser
Structure: contains 1 C-type lectin domain
Compartment: membrane
Expression:
- expressed exclusively in hepatic parenchymal cells
General
asialoglycoprotein receptor
Ca+2 binding protein
glycoprotein
Properties
SIZE: entity length = 291 aa
MW = 33 kD
COMPARTMENT: cellular membrane
MOTIF: Endocytosis signal {5-8}
cysteine residue {C36}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {41-61}
coiled coil {61-123}
MOTIF: N-glycosylation site {N79}
N-glycosylation site {N147}
cysteine residue {C154}
MODIFICATION: cysteine residue {C165}
C-type lectin {161-278}
MOTIF: cysteine residue {C165}
MODIFICATION: cysteine residue {C154}
cysteine residue {C182}
MODIFICATION: cysteine residue {C277}
Ca+2-binding site
SITE: 191-191
Ca+2-binding site
SITE: 197-197
Ca+2-binding site
SITE: 216-216
Ca+2-binding site
SITE: 240-240
binding site
SITE: 240-240
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 242-242
Ca+2-binding site
SITE: 243-243
binding site
SITE: 244-244
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 253-253
binding site
SITE: 253-253
FOR-BINDING-OF: Carbohydrate
Ca+2-binding site
SITE: 254-254
cysteine residue {C255}
MODIFICATION: cysteine residue {C269}
Ca+2-binding site
SITE: 265-265
Ca+2-binding site
SITE: 266-266
cysteine residue {C269}
MODIFICATION: cysteine residue {C255}
cysteine residue {C277}
MODIFICATION: cysteine residue {C182}
Ca+2-binding site
SITE: 278-278
Database Correlations
OMIM 108360
UniProt P07306
PFAM correlations
Entrez Gene 432
Kegg hsa:432
References
- UniProt :accession P07306
- Functional glycomics gateway - glycan binding
Note: hepatic asialoglycoprotein receptor subunit 1
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_215