histone chaperone ASF1B (anti-silencing function protein 1 homolog B, hAsf1, hAsf1b, CCG1-interacting factor A-II, CIA-II, hCIA-II, ASF1B)

Function: - histone chaperone - facilitates histone deposition & histone exchange & removal during nucleosome assembly & disassembly - cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly - does not participate in replication-independent nucleosome deposition mediated by ASF1A & HIRA - required for spermatogenesis - interacts with histone H3 (including both histone H3.1 & H3.3) & histone H4 - interacts with the CHAF1A, CHAF1B & RBBP4 subunits of the CAF-1 complex - interacts with HAT1, NASP, TAF1, TLK1 & TLK2 - phosphorylated by TLK1 & TLK2 Structure: belongs to the ASF1 family Compartment: nucleus Expression: - highly expressed in testis - lower levels in colon, small intestine & thymus

Properties

SIZE: MW = 22 kD entity length = 202 aa COMPARTMENT: cell nucleus MOTIF: histone H3 interaction {1-156} MOTIF: CHAF1B interaction {1-155}

Database Correlations

UniProt Q9NVP2 Pfam PF04729

References

UniProt :accession Q9NVP2