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histone chaperone ASF1A (anti-silencing function protein 1 homolog A, hAsf1, hAsf1a, CCG1-interacting factor A, CIA, hCIA, ASF1A)
Function:
- histone chaperone
- facilitates histone deposition & histone exchange & removal during nucleosome assembly & disassembly
- cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly & with HIRA to promote replication-independent chromatin assembly
- required for formation of senescence-associated heterochromatin foci (SAHF) & efficient senescence-associated cell cycle exit
- interacts with histone H3 (both histone H3.1 & histone H3.3) & histone H4
- interacts with the CHAF1A, CHAF1B & RBBP4 subunits of the CAF-1 complex
- interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 & UBN1
- phosphorylated by TLK1 & TLK2
- highly phosphorylated in S-phase & at lower levels in M-phase
Structure: belongs to the ASF1 family
Compartment: nucleus
Expression:
- ubiquitously expressed
- diminished expression of ASF1A associated with longevity [2]
General
chaperonin; chaperone
phosphoprotein
Properties
SIZE: MW = 23 kD
entity length = 204 aa
COMPARTMENT: cell nucleus
MOTIF: histone H3 interaction {1-156}
MOTIF: HIRA interaction {31-37}
required for interaction with HIRA {155-204}
Database Correlations
UniProt Q9Y294
Pfam PF04729
References
- UniProt :accession Q9Y294
- Passtoors WM
Transcriptional profiling of human familial longevity
indicates a role for ASF1A and IL7R.
PLoS One. 2012;7(1):e27759. Epub 2012 Jan 11.
PMID: 22247756